ea0065p236 | Metabolism and Obesity | SFEBES2019
Liu Charlotte Jenkins
, Adams Claire
, Church David
, Flanagan Catherine
, Gaff Lisa
, Jayne David
, Melvin Audrey
, O'Rahilly Stephen
, Pizirtzidou Eirini
, Savage David
, Semple Robert
, Withers Elaine
, Stears Anna
Introduction: Immune mediated cases of severe insulin resistant diabetes are very rare. We report responses to immunosuppression with rituximab in two patients.Case 1: A 31 year old black African female, BMI 22.84 kg/m², was referred with new onset diabetes, diagnosed shortly following a miscarriage. She had weight loss, acanthosis nigricans, nocturnal hypoglycaemia and severe hyperandrogenism . She was on an insulin pump and required >1000 units in...